Borax has the toxicity to humans, including reproductive and developmental toxicity, neurotoxicity, and nephrotoxicity. The degree of borax toxicity depends on the dose or concentration that the human received. The most sensitive endpoints of borax toxicity is developmental and reproductive toxicity [2]. Borax causes irritation of skin and respiratory tract. The gastrointestinal tract, skin, vascular system and brain are the principal organs and tissues affected. It causes nausea, persistant vomiting, abdominal pain, diarrhea, erythematous and exfoliative rash, unconsciousness, depression and renal failure.